Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10587115 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
Examples of ring-expanded nucleosides (RENs), represented by general structures 1 and 2, exhibited dual anti-HCV and anti-HIV activities in both cell culture systems and the respective target enzyme assays, including HCV NTPase/helicase and human RNA helicase DDX3. Since HCV is a leading co-infection in late stage HIV AIDS patients, often leading to liver cirrhosis and death, the observed dual inhibition of HCV and HIV by the target nucleoside analogues has potentially beneficial implications in treating HIV patients infected with HCV.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ning Zhang, Peng Zhang, Andrea Baier, Lucyna Cova, Ramachandra S. Hosmane,