| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10587237 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
The irreversible inhibition of acetylcholinesterase (AChE) by organophosphorous chemical warfare agents necessitates that antidotes be administered for effective treatment. Currently no antidote is known that resurrects the phosphyl-AChE complex once aging has occurred. This report characterizes the affinities of over 30 new AChE inhibitors which could act as resurrecting agents for the aged AChE-OP adduct.
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Authors
Joseph J. Topczewski, Alexander M. Lodge, Sumana N. Yasapala, Maurice K. Payne, Pedrom M. Keshavarzi, Daniel M. Quinn,