| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10587253 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
We developed a photoresponsive α-bromoaldehyde-conjugated oligonucleotide (PBA-ODN). The PBA-ODN selectively reacted and formed covalent bonds with target oligonucleotides having adenine or cytosine at the frontal position of the aldehyde derivative. Kinetic studies revealed that PBA-ODN has increased kinetic rates for the formation of cross-linked duplexes compared with the corresponding α-chloroaldehyde-conjugated oligonucleotide (PCA-ODN).
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Akio Kobori, Yuko Nagae, Yuta Sugihara, Asako Yamayoshi, Akira Murakami,