Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10587257 | Bioorganic & Medicinal Chemistry Letters | 2013 | 7 Pages |
Abstract
A sub-class of distinct small molecule ROMK inhibitors were developed from the original lead 1. Medicinal chemistry endeavors led to novel ROMK inhibitors with good ROMK functional potency and improved hERG selectivity. Two of the described ROMK inhibitors were characterized for the first in vivo proof-of-concept biology studies, and results from an acute rat diuresis model confirmed the hypothesis that ROMK inhibitors represent new mechanism diuretic and natriuretic agents.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Haifeng Tang, Reynald K. de Jesus, Shawn P. Walsh, Yuping Zhu, Yan Yan, Birgit T. Priest, Andrew M. Swensen, Magdalena Alonso-Galicia, John P. Felix, Richard M. Brochu, Timothy Bailey, Brande Thomas-Fowlkes, Xiaoyan Zhou, Lee-Yuh Pai, Caryn Hampton,