Article ID Journal Published Year Pages File Type
10587287 Bioorganic & Medicinal Chemistry Letters 2013 6 Pages PDF
Abstract
A new family of 30 benzoylated N-ylides 4 and 5 was synthesized and evaluated for the inhibitory activity on human protein farnesyltransferase. Most of these novel compounds possessed in vitro inhibition potencies in the micromolar range. The nature of the substituents on the pyridine and phenyl units proved to be important in determining inhibitory activity and generally, the replacement of the cyanoacrylonitrile function by a cyanoethylacrylate group decreased the biological potential on farnesyltransferase. These results completed our SAR study on this original class of N-ylides.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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