Article ID Journal Published Year Pages File Type
10587303 Bioorganic & Medicinal Chemistry Letters 2013 4 Pages PDF
Abstract
An antimalarial medicinal plant Picrorhiza scrophulariiflora was chemically investigated as part of our ongoing research in traditional chinese medicines (TCM). Mass directed fractionation of the active part of the crude extract led to the isolation of ten main components, three new compounds (1-3) and seven known compounds (4-10). Compound 10 inhibited the growth of the Plasmodium falciparum 3D7 malarial parasite line, with an IC50 value of 8.3 μM. This compound accounted for ∼95% of P. falciparum growth inhibitory activity in the crude extract confirming, for this TCM, that a single compound was responsible for the antimalarial activity.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
, , , , , ,