Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10587312 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
Microwave accelerated reaction system (MARS) technology provided a good method to obtain selective and open isoxazole ligands that bind to and inhibit the Sxc- antiporter. The MARS provided numerous advantages, including: shorter time, better yield and higher purity of the product. Of the newly synthesized series of isoxazoles the salicyl hydrazide 6 exhibited the highest level of inhibitory activity in the transport assay. A homology model has been developed to summarize the SAR results to date, and provide a working hypothesis for future studies.
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Authors
Afnan A. Matti, Joseph Mirzaei, John Rudolph, Stephen A. Smith, Jayme L. Newell, Sarjubhai A. Patel, Michael R. Braden, Richard J. Bridges, Nicholas R. Natale,