| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10587342 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
A novel series of non-imidazole bicyclic and tricyclic histamine H3 receptor antagonists has been discovered. Compound 17 was identified as a centrally penetrant molecule with high receptor occupancy which demonstrates robust oral activity in rodent models of obesity. In addition compound 17 possesses clean CYP and hERG profiles and shows no behavioral changes in the Irwin test.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Manuel de Lera Ruiz, Junying Zheng, Michael Y. Berlin, Kevin D. McCormick, Robert G. Aslanian, Robert West, Joyce Hwa, Jean Lachowicz, Margaret van Heek,