Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10587347 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
This letter describes the mechanism behind the protective effect of 4-phenylbutyric acid (4-PBA) against endoplasmic reticulum (ER) stress-induced neuronal cell death using three simple 4-(p-substituted phenyl) butyric acids (4-PBA derivatives). Their relative human histone deacetylase (HDAC) inhibitory activities were consistent with a structural model of their binding to HDAC7, and their ability to suppress neuronal cell death and activity of chemical chaperone in vitro. These data suggest that 4-PBA protects against neuronal cell death mediated by the chemical chaperone activity rather than by inhibition of histone deacetylase.
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Authors
Seisuke Mimori, Hiroyasu Ohtaka, Yukari Koshikawa, Koichi Kawada, Masayuki Kaneko, Yasunobu Okuma, Yasuyuki Nomura, Yasuoki Murakami, Hiroshi Hamana,