| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10587352 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
The synthesis of an isosteric analog of the natural product and HDAC inhibitor largazole is described. The sulfur atom in the thizaole ring of the natural product has been replaced with an oxygen atom, constituting an oxazole ring. The biochemical activity and cytotoxicity of this species is described.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jennifer M. Guerra-Bubb, Albert A. Bowers, William B. Smith, Ronald Paranal, Guillermina Estiu, Olaf Wiest, James E. Bradner, Robert M. Williams,