Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10587556 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
The first synthesis of the non-peptidic snail toxin 6-bromo-2-mercaptotryptamine dimer (BrMT)2 is described, along with the preparation of its lower and higher thio homologs. The synthetic (BrMT)2 and its derivatives reported herein are all capable of slowing the activation of the Kv1.1 potassium ion channel. Only the monosulfide variant shows significant slowing of the deactivation process. This synthetic strategy can now be applied to creating a more extensive set of compounds that vary in the length of the linker connecting the two monomers, the substituents on the indole ring core, and terminal amine.
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Authors
Detian Gao, Rheanna Sand, Hao Fu, Nazlee Sharmin, Warren J. Gallin, Dennis G. Hall,