Article ID Journal Published Year Pages File Type
10587583 Bioorganic & Medicinal Chemistry Letters 2013 6 Pages PDF
Abstract
A series of heterocyclic glucocorticoid receptor (GR) modulators with 2,2-dimethyl-3-phenyl-N-(thiazol or thiadiazol-2-yl)propanamide core are described. Structure-activity relationships suggest a combination of H-bond acceptor and a 4-fluorophenyl moiety as being important structural components contributing to the glucocorticoid receptor binding and functional activity for this series of GR modulators.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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