| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10587583 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
A series of heterocyclic glucocorticoid receptor (GR) modulators with 2,2-dimethyl-3-phenyl-N-(thiazol or thiadiazol-2-yl)propanamide core are described. Structure-activity relationships suggest a combination of H-bond acceptor and a 4-fluorophenyl moiety as being important structural components contributing to the glucocorticoid receptor binding and functional activity for this series of GR modulators.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hai-Yun Xiao, Dauh-Rurng Wu, James E. II, Sium F. Habte, Mark D. Cunningham, John E. Somerville, Joel C. Barrish, Steven G. Nadler, T.G. Murali Dhar,