Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10587583 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
A series of heterocyclic glucocorticoid receptor (GR) modulators with 2,2-dimethyl-3-phenyl-N-(thiazol or thiadiazol-2-yl)propanamide core are described. Structure-activity relationships suggest a combination of H-bond acceptor and a 4-fluorophenyl moiety as being important structural components contributing to the glucocorticoid receptor binding and functional activity for this series of GR modulators.
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Authors
Hai-Yun Xiao, Dauh-Rurng Wu, James E. II, Sium F. Habte, Mark D. Cunningham, John E. Somerville, Joel C. Barrish, Steven G. Nadler, T.G. Murali Dhar,