Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10587613 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
Csypyrones B1, B2 and B3 are α-pyrones that can be obtained from Aspergillus oryzae expressing CsyB, which is a type III polyketide synthase. We investigated the biosynthesis of the csypyrone B compounds using [1-13C] and [2-13C] acetate feeding experiments. 13C NMR analyses of the methyl esters of the csypyrone B compounds fed with the 13C-labeled acetates showed that the carboxyl carbons of the csypyrone B side-chains were derived from the C-2 methyl carbon of the acetate. These results indicated that fatty acyl starters are involved in the CsyB reaction and that the csypyrone B compounds are formed by the oxidation of side-chains by the host fungus.
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Authors
Makoto Hashimoto, Satomi Ishida, Yasuyo Seshime, Katsuhiko Kitamoto, Isao Fujii,