Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10587678 | Bioorganic & Medicinal Chemistry Letters | 2013 | 13 Pages |
Abstract
Protein misfolding is an emerging field that crosses multiple therapeutic areas and causes many serious diseases. As the biological pathways of protein misfolding become more clearly elucidated, small molecule approaches in this arena are gaining increased attention. This manuscript will survey current small molecules from the literature that are known to modulate misfolding, stabilization or proteostasis. Specifically, the following targets and approaches will be discussed: CFTR, glucocerebrosidase, modulation of toxic oligomers, serum amyloid P (SAP) sections and HSF1 activators.
Related Topics
Physical Sciences and Engineering
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Authors
Rajiah Aldrin Denny, Lori Krim Gavrin, Eddine Saiah,