| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10587726 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
Twelve derivatives of oleanolic acid (1) have been synthesized and evaluated for their inhibitory activities against the growth of prostate PC3, breast MCF-7, lung A549, and gastric BGC-823 cancer cells by MTT assays. Within these series of derivatives, compound 17 exhibited the most potent cytotoxicity against PC3 cell line (IC50 = 0.39 μM) and compound 28 displayed the best activity against A549 cell line (IC50 = 0.22 μM). SAR analysis indicates that H-donor substitution at C-3 position of oleanolic acid may be advantageous for improvement of cytotoxicity against PC3, A549 and MCF-7 cell lines.
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Authors
Jia Hao, Jun Liu, Xiaoan Wen, Hongbin Sun,