| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10587739 | Bioorganic & Medicinal Chemistry Letters | 2013 | 8 Pages |
Abstract
A series of thiazole bearing thiazolidin-4-one was discovered via high-throughput screening as non-competitive inhibitors of ADAMTS-5. Compound 31 appeared to give the best ADAMTS-5 inhibition and good selectivity over other metalloproteases.
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Authors
Masakazu Atobe, Naomi Maekawara, Noriko Ishiguro, Shinya Sogame, Yoshihito Suenaga, Masashi Kawanishi, Hiroko Suzuki, Norimasa Jinno, Eiichi Tanaka, Shiro Miyoshi,