| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10587742 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
A series of 1,1-dioxothieno[2,3-d]isothiazole (thienosultam) derivatives were designed and synthesized as novel ADAMTS-5 inhibitors for an investigation into a side chain of thienosultam for the S1â² pocket. The resulting compounds (19 and 24) show high ADAMTS-5 inhibition and other MMP selectivity, and these compounds show good oral bioavailability.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Masakazu Atobe, Naomi Maekawara, Masashi Kawanishi, Hiroko Suzuki, Eiichi Tanaka, Shiro Miyoshi,