| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10587750 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
Development of SAR in a 5-aryl-3-acylpyridinyl-pyrazoles and 1-aryl-4-acylpyridinylimidazoles series of mGlu5 receptor negative allosteric modulators (mGluR5 NAMs) using a functional cell-based assay is described in this Letter. Analysis of the Ligand-lipophilic efficiency (LipE) of compounds provided new insight for the design of potent mGluR5 negative allosteric modulators with anti-depressant activities.
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Authors
Eunhee Chae, Yong-Je Shin, Eun-Ju Ryu, Mi Kyung Ji, Nahm Ryune Cho, Ki-Ho Lee, Hyun Ji Jeong, Soo-Jin Kim, Yeonjung Choi, Kyung Seok Oh, Chun-Eung Park, Young Soo Yoon,