Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10587755 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
Three new unique sesquiterpenes, euryspongins A-C (1-3), were isolated from a marine sponge Euryspongia sp. collected at Iriomote Island, Okinawa, Japan. Compound 1 possessed a bicyclic furanosesquiterpene structure with six- and eight-membered rings, whereas compounds 2 and 3 had an α,β-unsaturated-γ-lactone ring instead of the furan ring in 1. Only five natural products in this class have been reported, and compounds 1-3 are the sixth-eighth examples of natural products. Compounds 1-3 had no inhibition effect against PTP1B, an important target enzyme for the treatment of diabetes, while the dehydro derivative of 1 [dehydroeuryspongin A (4)] exhibited inhibitory activity (IC50 = 3.6 μM).
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hiroyuki Yamazaki, Takahiro Nakazawa, Deiske A. Sumilat, Ohgi Takahashi, Kazuyo Ukai, Shiori Takahashi, Michio Namikoshi,