Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10587764 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
Guided by co-crystal structures of compounds 15, 22 and 30, an SBDD approach led to the discovery of the 6-methyl pyridone series as a novel class of GKAs that potently activate GK in enzyme and cell assays. Anti-diabetic OGTT efficacy was demonstrated with 54 in a mouse model of type 2 diabetes.
Related Topics
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Chemistry
Organic Chemistry
Authors
Zacharia S. Cheruvallath, Stephen L. II, Mark Sabat, Mingnam Tang, Jun Feng, Haixia Wang, Joanne Miura, Prasuna Guntupalli, Andy Jennings, David Hosfield, Bumsup Lee, Yiqin Wu,