| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10587764 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
Guided by co-crystal structures of compounds 15, 22 and 30, an SBDD approach led to the discovery of the 6-methyl pyridone series as a novel class of GKAs that potently activate GK in enzyme and cell assays. Anti-diabetic OGTT efficacy was demonstrated with 54 in a mouse model of type 2 diabetes.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zacharia S. Cheruvallath, Stephen L. II, Mark Sabat, Mingnam Tang, Jun Feng, Haixia Wang, Joanne Miura, Prasuna Guntupalli, Andy Jennings, David Hosfield, Bumsup Lee, Yiqin Wu,