Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10587894 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
A series of highly potent & selective adamantane derived CB2 agonists was identified in a high-throughput screen. A SAR was established and physicochemical properties were significantly improved. This was accompanied by potency of the compounds on the Q63R variant and varying β-arrestin data which will support the insight into their relevance for the in vivo situation.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Matthias Nettekoven, Jürgen Fingerle, Uwe Grether, Sabine Grüner, Atsushi Kimbara, Bernd Püllmann, Mark Rogers-Evans, Stephan Röver, Franz Schuler, Tanja Schulz-Gasch, Christoph Ullmer,