Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10587900 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
Four series of acid amides were synthesized, preliminary structure-activity relationship analysis indicated that caffeic acid amides with electron-donating groups at para-position of amino phenyl group showed better inhibitory activities and selectivity than those with electron-withdrawing groups, and the presence of adjacent dihydroxy in the caffeoyl group was very important for the MMP-2 and MMP-9 inhibitory activities.
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Authors
Zhi-Hao Shi, Nian-Guang Li, Qian-Ping Shi, Hao Tang, Yu-Ping Tang, Wei Li, Lian Yin, Jian-Ping Yang, Jin-Ao Duan,