| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10587901 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
The optimization of a novel series of highly potent and selective dual inhibitors of mTORC1 and mTORC2 is described culminating in the discovery of clinical candidates AZD8055 (14) and AZD2014 (21).
Related Topics
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Organic Chemistry
Authors
Kurt G. Pike, Karine Malagu, Marc G. Hummersone, Keith A. Menear, Heather M.E. Duggan, Sylvie Gomez, Niall M.B. Martin, Linette Ruston, Sarah L. Pass, Martin Pass,