Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10587915 | Bioorganic & Medicinal Chemistry Letters | 2013 | 7 Pages |
Abstract
The discovery, structure-based design, synthesis, and optimization of NIK inhibitors are described. Our work began with an HTS hit, imidazopyridinyl pyrimidinamine 1. We utilized homology modeling and conformational analysis to optimize the indole scaffold leading to the discovery of novel and potent conformationally constrained inhibitors such as compounds 25 and 28. Compounds 25 and 31 were co-crystallized with NIK kinase domain to provide structural insights.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kexue Li, Lawrence R. McGee, Ben Fisher, Athena Sudom, Jinsong Liu, Steven M. Rubenstein, Mohmed K. Anwer, Timothy D. Cushing, Youngsook Shin, Merrill Ayres, Fei Lee, John Eksterowicz, Paul Faulder, Bohdan Waszkowycz, Olga Plotnikova, Ellyn Farrelly,