Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10587960 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
Two new steroids, (2β,3β,4α,5α,8β)-4-methylergost-24(28)-ene-2,3,8-triol (1) and (3β,7α)-24-methyl-7-hydroperoxycholest-5,24(28)-diene-3-ol (2), together with 13 known analogues (3-15) were isolated from the soft coral Sinularia depressa Tixier-Durivault. The structures of the new compounds were elucidated by detailed spectroscopic analysis and comparison with reported data. In the bioassay in vitro, compounds 3a, 4, and 14 exhibited potent PTP1B inhibitory activity, being similar as that of positive control oleanolic acid. Compound 14 also displayed a notable neuroprotective activity against both amyloid-β25-35- and serum deprivation-induced injuries in SH-SY5Y cells while compound 11 showed a considerable antibacterial activity against Staphylococcus aureus. Preliminary structure-activity relationships of these steroids were discussed.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lin-Fu Liang, Xu-Jie Wang, Hai-Yan Zhang, Hai-Li Liu, Jia Li, Le-Fu Lan, Wen Zhang, Yue-Wei Guo,