| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10587981 | Bioorganic & Medicinal Chemistry Letters | 2013 | 7 Pages |
Abstract
The docking poses of the alkylides 17, 18, 19 and 20 overlapped with the crystal structure of clarithromycin. Our molecular modeling results for 17-20 shed light on the reason why the sidechains' conformational flexibility at the 3-O position has a significant impact on their antibacterial activity.
Related Topics
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Organic Chemistry
Authors
Jian-Hua Liang, Wei Lv, Xiao-Li Li, Kun An, Mark Cushman, He Wang, Ying-Chun Xu,