| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588026 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
Pyrolidine ring in the N-acylphenylalanine class of VLA-4 antagonists has been successfully replaced by a 4,5-dihydro-5-methylisoxazoline and resulting derivative (14p) found to be potent in the series and also found to be metabolically stable in vitro.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ajay Soni, Abdul Rehman, Keshav Naik, Sunanda Dastidar, M.S. Alam, Abhijit Ray, Tridib Chaira, Vanya Shah, Venkata P. Palle, Ian A. Cliffe, Viswajanani J. Sattigeri,