Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10588140 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
A series of novel ligands based on the diaryl anilide (DAA) class of translocator protein (TSPO) ligands was synthesised and evaluated as potential positron emitting tomography (PET) ligands for imaging TPSO in vivo. Fluorine-18 labelling of the molecules was achieved using direct radiolabelling or synthon based labelling approaches. Several of the ligands prepared have promising profiles as potential TSPO PET imaging ligands and will be evaluated further as potential clinical imaging agents.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Harry Wadsworth, Paul A. Jones, Wai-Fung Chau, Clare Durrant, Véronique Morisson-Iveson, Joanna Passmore, Dennis O'Shea, Duncan Wynn, Imtiaz Khan, Andrew Black, Michelle Avory, William Trigg,