Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10588150 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
An efficient synthesis of racemic and both enantiomeric forms of heteroaryl substituted γ- and δ-lactone derivatives derived from allyl and homoallyl alcohol backbones has been accomplished via ring closing metathesis reaction. 2-Heteroaryl substituted allyl and homoallyl alcohols have been efficiently resolved through enzymatic method with high ee (97-99%) and known stereochemistry. Antimicrobial and antioxidant activities of target lactones were evaluated.
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Authors
Melis Åardan, Serdar Sezer, Aslıhan Günel, Mahinur Akkaya, Cihangir Tanyeli,