| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588185 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Structure-activity relationship studies of oxysterol 4 have identified analogues such as 18, 21 and 30. These analogues are characterized by higher potency in a osteoblast differentiation assay and/or by increased metabolic stability in human liver microsomes. Oxysterols 4, 18 and 21 were evaluated in vivo in a rat spinal fusion model.
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Authors
Frank Stappenbeck, Wei Xiao, Matt Epperson, Mariko Riley, Aaron Priest, Danwen Huang, KhanhLinh Nguyen, Michael E. Jung, R. Scott Thies, Francine Farouz,