Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10588195 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
We report the discovery of new potent inhibitors of the growth of Plasmodium falciparum chloroquine (CQ)-resistant W2 strain. These compounds were designed using the double drug approach by introducing a residue able to enhance the accumulation of plasmepsins inhibitors into the food vacuole. Some of the molecules were more active than CQ against CQ-resistant strain and showed good selectivity against cathepsin D.
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Authors
Nadia Vaiana, Melissa Marzahn, Silvia Parapini, Peng Liu, Mario Dell'Agli, Andrea Pancotti, Enrico Sangiovanni, Nicoletta Basilico, Enrica Bosisio, Ben M. Dunn, Donatella Taramelli, Sergio Romeo,