| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588228 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
This manuscript concludes the Structure Activity Relationship (SAR) on the pyridazinone scaffold and identifies a compound with subnanomolar p38α activity and 24 h coverage in the rat arthritis efficacy model.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Robert M. Tynebor, Meng-Hsin Chen, Swaminathan R. Natarajan, Edward A. O'Neill, James E. Thompson, Catherine E. Fitzgerald, Stephen J. O'Keefe, James B. Doherty,