Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10588245 | Bioorganic & Medicinal Chemistry Letters | 2012 | 8 Pages |
Abstract
Here in, we report the usage of cellulose sulfuric acid as a heterogeneous eco friendly catalyst for the synthesis of 1,4 dihydropyridines under solvent free conditions via Hantzsch three component reaction of an aldehyde, ethyl acetoacetate and ammonium acetate at 100 °C for 2-5 h. In silico studies were performed on twenty two possible 1,4 dihydropyridines (DHPs) analogues against K+ channel receptor (KcsA). In order to validate in silico studies, thirteen compounds were synthesized and evaluated as antibacterials against twenty seven ESBL isolates of Klebsiella pneumoniae and Escherichia coli.
Related Topics
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Authors
Y.L.N. Murthy, Abdul Rajack, M. Taraka Ramji, J. Jeson babu, Ch. Praveen, K. Aruna Lakshmi,