| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588367 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A novel ratiometric fluorescent peptidyl chemosensor (Dansyl-Cys-Pro-Gly-Cys-Trp-NH2, D-P5) for metal ions detection has been synthesized via Fmoc solid-phase peptide synthesis. The chemosensor exhibited a high selectivity for Cd2+ over other metal ions including competitive transition and Group I and II metal ions in neutral pH. The fluorescence emission intensity of D-P5 was significantly enhanced in the presence of Cd2+ by fluorescent resonance energy transfer (FRET) and chelation enhanced fluorescence (CHEF) effects. The binding stoichiometry, detection limit, binding affinity, reversibility and pH sensitivity of the sensor for Cd2+ were investigated.
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Authors
Yan Li, Lianzhi Li, Xuewei Pu, Guolin Ma, Erqiong Wang, Jinming Kong, Zhipeng Liu, Yangzhong Liu,