| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588374 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
A new class of PDF inhibitor with potent, broad spectrum antibacterial activity is described. Optimization of blood stability and potency provided compounds with improved pharmacokinetics that were suitable for in vivo experiments. Compound 5c, which has robust antibacterial activity, demonstrated efficacy in two respiratory tract infection models.
Related Topics
Physical Sciences and Engineering
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Organic Chemistry
Authors
Jeffrey M. Axten, Jesús R. Medina, Charles W. Blackledge, Céline Duquenne, Seth W. Grant, Mark A. Bobko, Tony Peng, William H. Miller, Theresa Pinckney, Timothy F. Gallagher, Swarupa Kulkarni, Thomas Lewandowski, Glenn S. Van Aller, Rimma Zonis,