| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588402 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
The role of the C8gem-dimethyl group in the A-ring of bryostatin 1 has been examined through chemical synthesis and biological evaluation of a new analogue. Assays for biological function using U937, K562, and MV4-11 cells as well as the profiles for downregulation of PKC isozymes revealed that the presence of this group is not a critical determinant for the unique pattern of biological activity of bryostatin.
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Authors
Gary E. Keck, Yam B. Poudel, Arnab Rudra, Jeffrey C. Stephens, Noemi Kedei, Nancy E. Lewin, Peter M. Blumberg,