Article ID Journal Published Year Pages File Type
10588402 Bioorganic & Medicinal Chemistry Letters 2012 5 Pages PDF
Abstract
The role of the C8gem-dimethyl group in the A-ring of bryostatin 1 has been examined through chemical synthesis and biological evaluation of a new analogue. Assays for biological function using U937, K562, and MV4-11 cells as well as the profiles for downregulation of PKC isozymes revealed that the presence of this group is not a critical determinant for the unique pattern of biological activity of bryostatin.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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