| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588412 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
Potent antagonists of the integrin α5β1, which are RGD mimetics built from tyrosine are described. This letter describes the optimization of in vitro potency obtained by variation of two parts of the molecule, the basic group and the linker between the basic group and the phenyl central core.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bénédicte Delouvrié, Katherine Al-Kadhimi, Jean-Claude Arnould, Simon T. Barry, Darren A.E. Cross, Myriam Didelot, Paul R. Gavine, Hervé Germain, Craig S. Harris, Adina M. Hughes, David A. Jude, Jane Kendrew, Christine Lambert-van der Brempt,