| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588413 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Potent antagonists of the integrin α5β1, which are RGD mimetics built from tyrosine are described. This paper describes the optimization of in vitro potency obtained by variation of two parts of the molecule, the central aromatic core and the amide moiety.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bénédicte Delouvrié, Katherine Al-Kadhimi, Jean-Claude Arnould, Simon T. Barry, Darren A.E. Cross, Myriam Didelot, Paul R. Gavine, Hervé Germain, Craig S. Harris, Adina M. Hughes, David A. Jude, Jane Kendrew, Christine Lambert-van der Brempt,