Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10588418 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
A series of 2â²-C-methyl branched purine and pyrimidine C-nucleosides were prepared. Their anti-HCV activity and pharmacological properties were profiled, and compared with known 2â²-C-Me N-nucleoside counterparts. In particular, 2â²-C-Me 4-aza-7,9-dideazaadenosine C-nucleoside (2) was found to have potent and selective anti-HCV activity in vitro as well as a favorable pharmacokinetic profile and in vivo potential for enhanced potency over the corresponding N-nucleoside.
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Authors
Aesop Cho, Lijun Zhang, Jie Xu, Darius Babusis, Thomas Butler, Rick Lee, Oliver L. Saunders, Ting Wang, Jay Parrish, Jason Perry, Joy Y. Feng, Adrian S. Ray, Choung U. Kim,