| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588427 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A PECAM-1 specific PET imaging agent, PECAM-1-Ab-DOTA-64Cu, was synthesized by conjugating the anti-mouse PECAM-1 antibody with 2,2â²,2â³,2â³â²-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (DOTA) and subsequent labeling with 64Cu. Positron Emission Tomography (PET) was successfully performed in a mouse model of myocardial infarction (MI) induced by an ischemia/reperfusion (I/R) injury, indicating the elevated expression of PECAM-1.
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Authors
Li Xiao, Yi Zhang, Zequan Yang, Yaqin Xu, Bijoy Kundu, Mahendra D. Chordia, Dongfeng Pan,