| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588432 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
The discovery and optimization of a novel series of N-type calcium channel blockers are described. Compound 16 has low nanomolar potency against the N-type and is highly selective relative to the L-type calcium and hERG potassium channels.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hassan Pajouhesh, Zhong-Ping Feng, Lingyun Zhang, Hossein Pajouhesh, Xinpo Jiang, Adam Hendricson, Haiheng Dong, Elizabeth Tringham, Yanbing Ding, Todd W. Vanderah, Frank Porreca, Francesco Belardetti, Gerald W. Zamponi, Lester A. Mitscher,