| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588590 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
The 2-(3-methylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes are potent and selective inhibitors of the Dopamine Transporter (DAT). Isoxazoles 6c (3β-(4-fluorophenyl)) and 6d (3β-(4-chlorophenyl)) inhibit the DAT (IC50 = 7 nM) and are inactive at Serotonin Transporter inhibition (IC50 >1000 nM).
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes](/preview/png/10588590.png "First Page Preview: The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes")
Authors
Madhusudhan Purushotham, Anjaneyulu Sheri, Duy-Phong Pham-Huu, Bertha K. Madras, Aaron Janowsky, Peter C. Meltzer,