| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588596 | Bioorganic & Medicinal Chemistry Letters | 2011 | 6 Pages |
Abstract
The discovery and SAR study of a novel 1,3,5-pyrazole series of human glucagon receptor antagonists represented by 26 are presented. Compound 26 was selective and orally active in several in vivo preclinical models of type II diabetes.
Related Topics
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Authors
Dong-Ming Shen, Edward J. Brady, Mari R. Candelore, Qing Dallas-Yang, Victor D.-H. Ding, William P. Feeney, Guoquiang Jiang, Margaret E. McCann, Steve Mock, Sajjad A. Qureshi, Richard Saperstein, Xiaolan Shen, Xinchun Tong, Laurie M. Tota,