Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10588600 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A series of tertiary amine analogs derived from lead azaaromatic quaternary ammonium salts has been designed and synthesized. The bis-tertiary amine analog 7 exhibited an IC50 of 0.95Â nM, while the tris-tertiary amine analog 19 had an IC50 of 0.35Â nM at nAChRs mediating nicotine-evoked dopamine release.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhenfa Zhang, Guangrong Zheng, Marharyta Pivavarchyk, A. Gabriela Deaciuc, Linda P. Dwoskin, Peter A. Crooks,