| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588622 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
High-throughput screening of 3.87Â million compounds delivered a novel series of non-steroidal GR antagonists. Subsequent rounds of optimisation allowed progression from a non-selective ligand with a poor ADMET profile to an orally bioavailable, selective, stable, glucocorticoid receptor antagonist.
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Authors
Angus R. Brown, Michael Bosies, Helen Cameron, John Clark, Angela Cowley, Mark Craighead, Moira A. Elmore, Alistair Firth, Richard Goodwin, Susan Goutcher, Emma Grant, Morag Grassie, Simon J.A. Grove, Niall M. Hamilton, Hannah Hampson, Alison Hillier,