Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10588636 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
We have previously disclosed a series of glucocorticoid receptor (GR) ligands derived from 6-indole-1,2,3,4-tetrahydroquinolines through structure-activity relationship (SAR) of the pendent C6-indole ring. In parallel with this effort, we now report SAR of the tetrahydroquinoline A-ring that identified the importance of a C3 hydroxyl in improving GR selectivity within a series of non-steroidal GR agonists.
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Authors
Steven L. Roach, Robert I. Higuchi, Andrew R. Hudson, Mark E. Adams, Peter M. Syka, Dale E. Mais, Jeffrey N. Miner, Keith B. Marschke, Lin Zhi,