Article ID Journal Published Year Pages File Type
10588646 Bioorganic & Medicinal Chemistry Letters 2011 4 Pages PDF
Abstract
Herein we describe the synthesis and structure activity relationship of a new class of FXR agonists identified from a high-throughput screening campaign. Further optimization of the original hits led to molecules that were highly active in an LDL-receptor KO model for dyslipidemia. The most promising candidate is discussed in more detail.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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