Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10588646 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
Herein we describe the synthesis and structure activity relationship of a new class of FXR agonists identified from a high-throughput screening campaign. Further optimization of the original hits led to molecules that were highly active in an LDL-receptor KO model for dyslipidemia. The most promising candidate is discussed in more detail.
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Authors
Hans G.F. Richter, Gregory M. Benson, Denise Blum, Evelyne Chaput, Song Feng, Christophe Gardes, Uwe Grether, Peter Hartman, Bernd Kuhn, Rainer E. Martin, Jean-Marc Plancher, Markus G. Rudolph, Franz Schuler, Sven Taylor, Konrad H. Bleicher,