Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10588657 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
We have developed a facile synthesis of 3,3-diphenylpropanamides using Meldrum's acid derivatives as amide coupling components. The in vitro biological evaluation of the title compounds led to the identification of compound 1h, which has good inhibitory activity against T-type calcium channel (IC50 = 0.83 μM).
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yeon-hee Choi, Du Jong Baek, Seon Hee Seo, Jae Kyun Lee, Ae Nim Pae, Yong Seo Cho, Sun-Joon Min,