Article ID Journal Published Year Pages File Type
10588657 Bioorganic & Medicinal Chemistry Letters 2011 5 Pages PDF
Abstract
We have developed a facile synthesis of 3,3-diphenylpropanamides using Meldrum's acid derivatives as amide coupling components. The in vitro biological evaluation of the title compounds led to the identification of compound 1h, which has good inhibitory activity against T-type calcium channel (IC50 = 0.83 μM).
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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