| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588689 | Bioorganic & Medicinal Chemistry Letters | 2011 | 6 Pages |
Abstract
In this manuscript we wish to report the discovery of MK-7246 (4), a potent and selective CRTH2 (DP2) antagonist. SAR studies leading to MK-7246 along with two synthetic sequences enabling the preparation of this novel class of CRTH2 antagonist are reported. Finally, the pharmacokinetic and metabolic profile of MK-7246 is disclosed.
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Authors
Michel Gallant, Christian Beaulieu, Carl Berthelette, John Colucci, Michael A. Crackower, Chad Dalton, Danielle Denis, Yves Ducharme, Richard W. Friesen, Daniel Guay, François G. Gervais, Martine Hamel, Robert Houle, Connie M. Krawczyk, Birgit Kosjek,