Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10588713 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
The asymmetric total synthesis of the strongly cytotoxic phenanthroindolizidine alkaloid 3 was achieved. Using the same route, various derivatives were also synthesized. Cytotoxicity of those synthetic compounds and the in vivo antitumor efficacy of selected compounds were evaluated.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Takashi Ikeda, Takashi Yaegashi, Takeshi Matsuzaki, Syusuke Hashimoto, Seigo Sawada,